![]() ![]() "The current trend of increasing numbers of newly marketed grapefruit-affected drugs possessing substantial adverse clinical effects necessitates an understanding of this interaction and the application of this knowledge for the safe and effective use of drugs in general practice," the article concludes. Older people with a reduced ability to tolerate drug overdoses were at greatest risk. Combining the cholesterol-lowering drug simvastatin with a 200-millilitre glass of grapefruit juice once a day for three days more than trebled its concentration level. The list of danger medicines includes treatments for anxiety, depression, allergy, HIV infection, seizures, heart rhythm abnormalities and high cholesterol.Ī modest single helping of grapefruit can have an effect even if consumed hours before a drug is taken, say the scientists.įrequent exposure to grapefruit could make matters worse. This can effectively boost the dose of some drugs many times. The chemicals, called furanocoumarins, act on an enzyme in the gut that normally reduces the potency of medication. Other citrus fruits such as Seville oranges, used to make marmalade, and limes contained the same active ingredients that caused the drug interactions. More than 85 drugs can interact with grapefruit, and of these 43 can have serious side effects, say the researchers. Grapefruit juice inhibits the CYP3A4 enzyme of the cytochrome P450 system in the intestinal mucosa, increasing the bioavailability of drugs with a high first. Potential cancer prevention: Due to its antioxidant lycopene content. Check OTC medicine warning labels and the instructions that come with prescription drugs to make sure that they don’t list grapefruit or other food-drug interactions. Heart health: Stemming from its solid potassium levels. Your doctor or pharmacist may tell you to avoid having grapefruit while taking certain medications. Inflammation reduction: Via the fruits anti-inflammatory flavonoids. Thus, we contend that there remains a lack of knowledge about this interaction in the general healthcare community." Research shows grapefruit helps promote: Wound healing: Likely thanks to vitamin C. Calcium channel blockers are used for high blood pressure and angina, explains Harvard Health Publishing. "In addition, the patient may not volunteer this information. Calcium Channel Blockers and Statins + Grapefruit. The article says: "Unless healthcare professionals are aware of the possibility that the adverse event they are seeing might have an origin in the recent addition of grapefruit to the patient's diet, it is very unlikely that they will investigate it. Each year, more than six of these drugs on average were being made available to patients.ĭr David Bailey, from Lawson Health Research Institute in London, Ontario, and colleagues described the trend as "disturbing". Between 20 the number of medications with the potential to cause serious harm by interacting with grapefruit increased from 17 to 43, according to scientists writing in the Canadian Medical Association Journal. ![]()
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